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Article

Cell‐autonomous sex determination outside of the gonad

30 Jan 2013

Abstract excerpt

BACKGROUND: The classic model of sex determination in mammals states that the sex of the individual is determined by the type of gonad that develops, which in turn determines the gonadal hormonal milieu that creates sex differences outside of the gonads. However, XX and XY cells are intrinsically different because of the cell-autonomous sex-biasing action of X and Y genes. RESULTS: Recent studies of mice, in...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Hypothalamic control of reproductive hormones
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PMID: 23361913
DOI: 10.1002/dvdy.23936

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