Sex dependent gene activity in the human body

Abstract excerpt

Many pathophysiological mechanisms in human health and disease are dependent on sex. Systems biology approaches are successfully used to decipher human disease etiology, yet the effect of sex on gene network biology is mostly unknown. To address this, we used RNA-sequencing data of over 700 individuals spanning 24 tissues from the Genotype-Tissue Expression project to generate a whole-body gene activity map and qu...

Topics

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• Adipose Tissue and Metabolism
• Drug Discovery
• Gene Expression
• Gene Regulatory Networks
• Genetic Predisposition to Disease
• Genotype
• Sequence Analysis, RNA
• Sex Factors

Identifiers and source

Literature Corpus work

c87f9f46-ca5c-587e-a6ef-7d652916ee82

DOI

10.1101/2020.04.22.055053