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Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment

2022-09-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Biological sex impacts susceptibility and presentation of cardiovascular disease, which remains the leading cause of death for both sexes. To reduce cardiovascular disease risk, statin drugs are commonly prescribed to reduce circulating cholesterol levels through inhibition of cholesterol synthesis. The effectiveness of statin therapy differs between individuals with a sex b...

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Literature Corpus work
771d484c-471c-59f2-b654-3e0fef94f73e
DOI
10.1101/2022.08.29.505758
Open publication

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Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatmentDOI 10.1101/2022.08.29.505758
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