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Harnessing natural variation to identify <i>cis</i> regulators of sex-biased gene expression in a multi-strain mouse liver model

2021-05-11

Abstract excerpt

Sex differences in gene expression are widespread in the liver, where a large number of autosomal factors act in tandem with growth hormone signaling to regulate individual variability of sex differences in liver metabolism and disease. Here, we compare hepatic transcriptomic and epigenetic profiles of mouse strains C57Bl/6J and CAST/EiJ, representing two subspecies separated by 0.5-1 million years of evolution, t...

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Literature Corpus work
13ea9e51-1e3d-5619-80d1-3652e3e06495
DOI
10.1101/2021.05.11.443564
Open publication

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Harnessing natural variation to identify <i>cis</i> regulators of sex-biased gene expression in a multi-strain mouse liver modelDOI 10.1101/2021.05.11.443564
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