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Article

Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model.

PLoS genetics - 1 Nov 2021

Matthews Bryan J, Melia Tisha, Waxman David J

Abstract excerpt

Sex differences in gene expression are widespread in the liver, where many autosomal factors act in tandem with growth hormone signaling to regulate individual variability of sex differences in liver metabolism and disease. Here, we compare hepatic transcriptomic and epigenetic profiles of mouse strains C57BL/6J and CAST/EiJ, representing two subspecies separated by 0.5-1 million years of evolution, to elucidate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34752452
DOI: 10.1371/journal.pgen.1009588
PMCID: PMC8664386

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