Article

Impact of mitochondrial fission and fusion on neuronal health and incidence of dementia

2024-12-23

Abstract excerpt

Mitochondria are highly dynamic structures that undergo constant remodeling by the process of fission and fusion. Using simulation methods we study the effects of neuron loss in humans due to the proliferation of deletion mutations. We implement two models of an organelle, namely, closed cristae (CC) and open mitochondrion (OM). With CC, mtDNA are confined to a cristae unless mixed by the process of fission and f...

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Literature Corpus work: 2824bb30-4fb5-5fa6-81a1-fea877d9b6c8
DOI: 10.1101/2024.12.21.629890

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