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Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging

28 Jun 2012

Abstract excerpt

Mitochondrial dynamics and mitophagy play a key role in ensuring mitochondrial quality control. Impairment thereof was proposed to be causative to neurodegenerative diseases, diabetes, and cancer. Accumulation of mitochondrial dysfunction was further linked to aging. Here we applied a probabilistic modeling approach integrating our current knowledge on mitochondrial biology allowing us to simulate mitochondrial...

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PMID: 22761564
DOI: 10.1371/journal.pcbi.1002576

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