Article

The long term effects of uncoupling interventions as a therapy for dementia in humans

2023-06-07

Abstract excerpt

In this paper we use simulation methods to study a hypothetical uncoupling agent as a therapy for dementia. We simulate the proliferation of mitochondrial deletion mutants amongst a population of wild-type in human neurons. Mitochondria play a key role in ATP generation. Clonal expansion can lead to the wild-type being overwhelmed by deletions such that a diminished population can no longer fulfill a cell's energy...

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Literature Corpus work: ec83457c-0a96-5b54-bb17-3143d9763f0e
DOI: 10.1101/2023.06.05.543670

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