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EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreas

22 Apr 2021

Abstract excerpt

As we age, our tissues are repeatedly challenged by mutational insult, yet cancer occurrence is a relatively rare event. Cells carrying cancer-causing genetic mutations compete with normal neighbors for space and survival in tissues. However, the mechanisms underlying mutant-normal competition in adult tissues and the relevance of this process to cancer remain incompletely understood. Here, we investigate how the...

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PMID: 33891893
DOI: 10.1016/j.cub.2021.03.094

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