Article

Oncogenic KRAS cells use Wnt signalling and cell dormancy to override homeostatic cell elimination mechanisms in adult pancreas.

2024-02-14

Abstract excerpt

Epithelial tissues use homeostatic defence mechanisms to actively expel aberrant or genetically mutant cells and prevent disease. When present in healthy tissues in low numbers, we show that cells expressing cancer-causing mutations (KrasG12D, p53R172H) compete with normal cells for survival and are often eliminated. Thus, tumour initiation must require mechanisms whereby mutant cells override tissue defence mecha...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dba3af8f-5532-5a86-b7a4-b99beec8f7aa
DOI: 10.1101/2024.02.13.579930

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Oncogenic KRAS cells use Wnt signalling and cell dormancy to override homeostatic cell elimination mechanisms in adult pancreas.DOI 10.1101/2024.02.13.579930Read

KRASG12D Cells Override Homeostatic Cell Elimination Mechanisms in Adult Pancreas Via Wnt5a and Cell Dormancy.Semantic proximity Read

KRASG12D mutant cells are outcompeted by wild type neighbours in adult pancreas in an EPHA2-dependent mannerSemantic proximity Read

EPHA2-dependent outcompetition of KRASG12D mutant cells by wild-type neighbors in the adult pancreasSemantic proximity Read

Defective apical extrusion signaling contributes to aggressive tumor hallmarksSemantic proximity Read

STAT3 Sustains Tumorigenicity Following Mutant KRAS AblationSemantic proximity Read

Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreasSemantic proximity Read

STAT3 sustains tumorigenicity following mutant KRAS ablation.Semantic proximity Read

Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells.Semantic proximity Read

Dormant Cancer Cells Contribute to Residual Disease in a Model of Reversible Pancreatic CancerSemantic proximity Read

A Novel Model of Pancreatic Cancer Dormancy Reveals Mechanistic Insights and a Dormancy Gene Signature with Human RelevanceSemantic proximity Read

Mutant clones in normal epithelium outcompete and eliminate emerging tumours.Semantic proximity Read

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cellsSemantic proximity Read