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Article

KRASG12D Cells Override Homeostatic Cell Elimination Mechanisms in Adult Pancreas Via Wnt5a and Cell Dormancy.

Gastroenterology - 1 Oct 2025

Salvador-Barbero Beatriz, Alatsatianos Markella, Morton Jennifer P, Sansom Owen J, Hogan Catherine

Abstract excerpt

BACKGROUND & AIMS: The adult pancreas protects against cancer by actively expelling genetically mutated cells. Pancreatic cancer starts with cells carrying KRAS mutations; however, it is not clear how some KRAS mutant cells override cell elimination mechanisms to survive in tissues. METHODS: An in vivo mouse model of sporadic tumorigenesis was used to induce Kras and/or Tp53 mutations in low numbers of cells in...

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Identifiers

PMID: 40204099
DOI: 10.1053/j.gastro.2025.02.042

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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