Article

Ephrin inhibition disrupts stromal-cancer crosstalk and reduces metastasis in pancreatic cancer

2025-12-13

Abstract excerpt

Cancer associated fibroblasts (CAFs) are critical drivers of disease progression and metastasis within the pancreatic tumour microenvironment. Using a 3D spheroid model of CAF-led invasion, we identified complementary expression of ephrin family receptors (EPHB2) and ligands (EPHRINB2) between cancer cells and CAFs, implicating this bidirectional signalling family in tumour progression. Through pancreatic stellate...

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Literature Corpus work: 46f1fc95-f5e8-5e1d-98d0-bf9255e42a2c
DOI: 10.64898/2025.12.10.693406

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