Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.

Nature cell biology - 1 May 2017

Jiang Kai, Rezabkova Lenka, Hua Shasha, Liu Qingyang, Capitani Guido, Altelaar A F Maarten, Heck Albert J R, Kammerer Richard A, Steinmetz Michel O, Akhmanova Anna

Abstract excerpt

ASPM (known as Asp in fly and ASPM-1 in worm) is a microcephaly-associated protein family that regulates spindle architecture, but the underlying mechanism is poorly understood. Here, we show that ASPM forms a complex with another protein linked to microcephaly, the microtubule-severing ATPase katanin. ASPM and katanin localize to spindle poles in a mutually dependent manner and regulate spindle flux. X-ray...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to HeLa Cells

Share to Microcephaly

Share to Microtubules

Share to Protein Interaction Domains and Motifs

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 28436967
DOI: 10.1038/ncb3511
PMCID: PMC5458804

Genes

ASPM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex.PMID 28436967Read ↗

Microcephaly protein Asp focuses the minus ends of spindle microtubules at the pole and within the spindle.Semantic proximity Read ↗

Human microcephaly ASPM protein is a spindle pole-focusing factor that functions redundantly with CDK5RAP2Semantic proximity Read ↗

The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein.Semantic proximity Read ↗

Human ASPM participates in spindle organisation, spindle orientation and cytokinesis.Semantic proximity Read ↗

An Asp-CaM complex is required for centrosome-pole cohesion and centrosome inheritance in neural stem cells.Semantic proximity Read ↗

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline.Semantic proximity Read ↗

The spindle assembly function of Caenorhabditis elegans katanin does not require microtubule-severing activity.Semantic proximity Read ↗

WDR62 localizes katanin at spindle poles to ensure synchronous chromosome segregationSemantic proximity Read ↗

The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and developmentSemantic proximity Read ↗

Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors.Semantic proximity Read ↗

DMob4/Phocein regulates synapse formation, axonal transport, and microtubule organization.Semantic proximity Read ↗

Microtubule plus-end tracking proteins in neuronal development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.