Article

A Modality-Aware CRISPR Actionability Framework for Functional Prioritization of Genome-Wide Significant Type 2 Diabetes Loci

2026-03-09

Abstract excerpt

<title>Abstract</title> <p>Genome-wide association studies (GWAS) have identified numerous loci associated with Type 2 Diabetes (T2D), yet translating statistical signals into experimentally testable hypotheses remains a central challenge in post-GWAS biology. The predominance of non-coding regulatory variants complicates target gene assignment and raises uncertainty regarding optimal CRISPR perturbation strategy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 27d33be7-8b2c-5e4d-8781-bf2bddec81a6
DOI: 10.21203/rs.3.rs-8957202/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Modality-Aware CRISPR Actionability Framework for Functional Prioritization of Genome-Wide Significant Type 2 Diabetes LociDOI 10.21203/rs.3.rs-8957202/v1Read

Multi-layered functional genomics prioritizes candidate effectors and regulatory mechanisms of ankylosing spondylitis.Semantic proximity Read

A practical view of fine-mapping and gene prioritization in the post-genome-wide association era.Semantic proximity Read

A genome-wide CRISPR screen identifies regulators of beta cell function involved in type 2 diabetes riskSemantic proximity Read

Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification.Semantic proximity Read

Saturation variant interpretation using CRISPR prime editing.Semantic proximity Read

Prioritization of genes associated with type 2 diabetes mellitus for functional studies.Semantic proximity Read

Identification of functional enhancer variants associated with type I diabetes in CD4+ T cells.Semantic proximity Read

Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits.Semantic proximity Read

Discovery of target genes and pathways at GWAS loci by pooled single-cell CRISPR screens.Semantic proximity Read

Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screens.Semantic proximity Read

High-Throughput Screening and CRISPR-Cas9 Modeling of Causal Lipid-Associated Expression Quantitative Trait Locus VariantsSemantic proximity Read

Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits.Semantic proximity Read