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Article

Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification.

Nature genetics - 1 May 2024

Ryu Jayoung, Barkal Sam, Yu Tian, Jankowiak Martin, Zhou Yunzhuo, Francoeur Matthew, Phan Quang Vinh, Li Zhijian, Tognon Manuel, Brown Lara, Love Michael I, Bhat Vineel, Lettre Guillaume, Ascher David B, Cassa Christopher A, Sherwood Richard I, Pinello Luca

Abstract excerpt

CRISPR base editing screens enable analysis of disease-associated variants at scale; however, variable efficiency and precision confounds the assessment of variant-induced phenotypes. Here, we provide an integrated experimental and computational pipeline that improves estimation of variant effects in base editing screens. We use a reporter construct to measure guide RNA (gRNA) editing outcomes alongside their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38658794
DOI: 10.1038/s41588-024-01726-6
PMCID: PMC11669423

Genes

LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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