Article

A genome-wide CRISPR screen identifies regulators of beta cell function involved in type 2 diabetes risk

2021-05-28

Abstract excerpt

Identification of the genes and processes mediating genetic association signals for complex disease represents a major challenge. Since many of the genetic signals for type 2 diabetes exert their effects through pancreatic islet-cell dysfunction, we performed a genome-wide pooled CRISPR loss-of- function screen in human pancreatic beta cells. We focused on the regulation of insulin content as a disease-relevant re...

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Literature Corpus work: 1d115a54-d7c6-51c4-a299-ba6e82647207
DOI: 10.1101/2021.05.28.445984

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