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Article

Emerging applications of genome-editing technology to examine functionality of GWAS-associated variants for complex traits.

Physiological genomics - 1 Jul 2018

Smith Andrew J P, Deloukas Panos, Munroe Patricia B

Abstract excerpt

Over the last decade, genome-wide association studies (GWAS) have propelled the discovery of thousands of loci associated with complex diseases. The focus is now turning toward the function of these association signals, determining the causal variant(s) among those in strong linkage disequilibrium, and identifying their underlying mechanisms, such as long-range gene regulation. Genome-editing techniques utilizing...

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Identifiers

PMID: 29652634
DOI: 10.1152/physiolgenomics.00028.2018
PMCID: PMC6087882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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