Article

Variable Schwann cell merlin inactivation is targetable with TEAD1 inhibition in schwannomas

2025-11-16

Abstract excerpt

Schwann cell tumors occur frequently in association with the vestibular nerves, leading to sensorineural hearing loss, and brainstem compression. In humans, unilateral vestibular schwannomas (VS) occur sporadically (VS spo ) 1 , or bilaterally with neurofibromatosis type 2 syndrome (NF2) – VS nf2 . 2 VS formation is driven by sub-haploid NF2 gene dosage 3 , typically by biallelic loss. 4,5 Loss of merlin pr...

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Literature Corpus work: 27be4c53-c496-5fa8-8026-360aec046a28
DOI: 10.1101/2025.11.15.688608

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