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MERLIN-DEFICIENT iPSCs AS AN <i>IN VITRO</i> MODEL SYSTEM FOR STUDIYNG <i>NF2</i> PATHOGENESIS

2022-12-14

Abstract excerpt

<h4>ABSTRACT</h4> NF2-related schwannomatosis is an autosomal dominant syndrome that predisposes to the development of benign tumors of the nervous system. Schwannomas, particularly bilateral vestibular schwannomas (VS), are the most characteristic features of the disease. These tumors are caused by the bi-allelic inactivation of the NF2 gene in a cell of the Schwann cell lineage. Our current understanding of th...

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Literature Corpus work
b0018c6d-d7f8-5aca-929a-b44fd16681c7
DOI
10.1101/2022.12.14.520389
Open publication

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