Article
Neurofibromatosis Type 2 (NF2) and the Implications for Vestibular Schwannoma and Meningioma Pathogenesis.
International journal of molecular sciences - 12 Jan 2021
Bachir Suha, Shah Sanjit, Shapiro Scott, Koehler Abigail, Mahammedi Abdelkader, Samy Ravi N, Zuccarello Mario, Schorry Elizabeth, Sengupta Soma
Abstract excerpt
Patients diagnosed with neurofibromatosis type 2 (NF2) are extremely likely to develop meningiomas, in addition to vestibular schwannomas. Meningiomas are a common primary brain tumor; many NF2 patients suffer from multiple meningiomas. In NF2, patients have mutations in the NF2 gene, specifically with loss of function in a tumor-suppressor protein that has a number of synonymous names, including: Merlin,...
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