The genomic landscape of schwannoma.

doi:10.1038/ng.3688

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Article

The genomic landscape of schwannoma.

Nature genetics - 1 Nov 2016

Agnihotri Sameer, Jalali Shahrzad, Wilson Mark R, Danesh Arnavaz, Li Mira, Klironomos George, Krieger Jonathan R, Mansouri Alireza, Khan Osaama, Mamatjan Yasin, Landon-Brace Natalie, Tung Takyee, Dowar Mark, Li Tiantian, Bruce Jeffrey P, Burrell Kelly E, Tonge Peter D, Alamsahebpour Amir, Krischek Boris, Agarwalla Pankaj Kumar, Bi Wenya Linda, Dunn Ian F, Beroukhim Rameen, Fehlings Michael G, Bril Vera, Pagnotta Stefano M, Iavarone Antonio, Pugh Trevor J, Aldape Kenneth D, Zadeh Gelareh

Abstract excerpt

Schwannomas are common peripheral nerve sheath tumors that can cause debilitating morbidities. We performed an integrative analysis to determine genomic aberrations common to sporadic schwannomas. Exome sequence analysis with validation by targeted DNA sequencing of 125 samples uncovered, in addition to expected NF2 disruption, recurrent mutations in ARID1A, ARID1B and DDR1. RNA sequencing identified a recurrent...

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PMID: 27723760
DOI: 10.1038/ng.3688

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HTRA1
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