Article
Next Generation Sequencing of Sporadic Vestibular Schwannoma: Necessity of Biallelic NF2 Inactivation and Implications of Accessory Non-NF2 Variants.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology - 1 Oct 2018
Carlson Matthew L, Smadbeck James B, Link Michael J, Klee Eric W, Vasmatzis George, Schimmenti Lisa A
Abstract excerpt
OBJECTIVES: 1) Describe the genetic alterations discovered in a series of sporadic vestibular schwannomas (VS). 2) Identify if more clinically aggressive variants possess different genetic alterations compared to more indolent-behaving VS. METHODS: Fresh frozen tumor and matched peripheral blood leukocytes from 23 individuals with sporadic VS were analyzed using whole-exome sequencing, tumor whole transcriptome...
Topics
- Adult
- Aged
- Aged, 80 and over
- Chromosome Disorders
- Female
- Gene Expression Profiling
- Genes, Neurofibromatosis 2
- High-Throughput Nucleotide Sequencing
- Humans
- Male
- Middle Aged
- Mutation