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Functional interactions between neurofibromatosis tumor suppressors drive Schwann cell tumor de-differentiation and treatment resistance

2022-08-11

Abstract excerpt

<title>Abstract</title> <p>Schwann cell tumors are the most common cancers of the peripheral nervous system and can arise sporadically or in patients with neurofibromatosis type-1 (NF-1) or type-2 (NF-2). NF-1 is caused by loss of NF1, a negative regulator of Ras signaling. NF-2 is caused by loss of NF2, a pleiotropic tumor suppressor that inhibits PAK signaling. Functional interactions between the NF1 and NF2 tu...

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Literature Corpus work
b8d3ffef-0af1-5e34-a27e-050490fab7b0
DOI
10.21203/rs.3.rs-1933793/v1
Open publication

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