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Article

Patient-derived cells from recurrent tumors that model the evolution of IDH-mutant glioma

1 Jan 2020

Abstract excerpt

Abstract Background IDH-mutant lower-grade gliomas (LGGs) evolve under the selective pressure of therapy, but well-characterized patient-derived cells (PDCs) modeling evolutionary stages are lacking. IDH-mutant LGGs may develop therapeutic resistance associated with chemotherapy-driven hypermutation and malignant progression. The aim of this study was to establish and characterize PDCs, single-cell-derived PDCs...

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Identifiers

PMID: 32904945
DOI: 10.1093/noajnl/vdaa088

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