Article

A novel method to identify cell-type specific regulatory variants and their role in cancer risk

2021-11-13

Abstract excerpt

<h4>Background</h4> Expression quantitative trait loci (eQTLs) have been crucial in providing an understanding of how genetic variants influence gene expression. However, eQTLs are known to exert cell type specific effects, and existing methods to identify cell type specific QTLs in bulk data require large sample sizes. <h4>Results</h4> Here, we propose DeCAF (DEconvoluted cell type Allele specific Function), a...

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Literature Corpus work: 278b6730-d0d6-5316-91a9-be512ac1f0d3
DOI: 10.1101/2021.11.11.468278

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