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Article

Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs.

PLoS genetics - 1 Jan 2013

Brown Christopher D, Mangravite Lara M, Engelhardt Barbara E

Abstract excerpt

Genetic variants in cis-regulatory elements or trans-acting regulators frequently influence the quantity and spatiotemporal distribution of gene transcription. Recent interest in expression quantitative trait locus (eQTL) mapping has paralleled the adoption of genome-wide association studies (GWAS) for the analysis of complex traits and disease in humans. Under the hypothesis that many GWAS associations tag...

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Identifiers

PMID: 23935528
DOI: 10.1371/journal.pgen.1003649
PMCID: PMC3731231

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