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Article

A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons.

PLoS genetics - 1 Jul 2020

Morton Derrick J, Jalloh Binta, Kim Lily, Kremsky Isaac, Nair Rishi J, Nguyen Khuong B, Rounds J Christopher, Sterrett Maria C, Brown Brianna, Le Thalia, Karkare Maya C, McGaughey Kathryn D, Sheng Shaoyi, Leung Sara W, Fasken Milo B, Moberg Kenneth H, Corbett Anita H

Abstract excerpt

The RNA exosome is an evolutionarily-conserved ribonuclease complex critically important for precise processing and/or complete degradation of a variety of cellular RNAs. The recent discovery that mutations in genes encoding structural RNA exosome subunits cause tissue-specific diseases makes defining the role of this complex within specific tissues critically important. Mutations in the RNA exosome component 3...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 32645003
DOI: 10.1371/journal.pgen.1008901
PMCID: PMC7373318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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