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Systematic comparison of pathogenic variants of the RNA exosome gene <i>EXOSC3/RRP40</i> in <i>Saccharomyces cerevisiae</i> reveals variant-specific functional consequences

2026-08-02

Abstract excerpt

<h4>ABSTRACT</h4> The RNA exosome is an essential, evolutionarily conserved ribonuclease complex that processes and degrades many classes of RNA. The complex is composed of three structural ‘cap’ subunits (EXOSC1-3/Csl4, Rrp4, Rrp40; H. sapiens/S. cerevisiae ), six structural ‘core’ subunits (EXOSC4-9/Rrp41,Rrp46,Mtr3,Rrp42,Rrp43,Rrp45), and a catalytic ribonuclease (DIS3 or DIS3L/Dis3). Cofactors that associate...

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Literature Corpus work
5adbc3c6-e4bb-5eaa-9a4d-4255bf4dedbc
DOI
10.64898/2026.07.29.741578
Open publication

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Systematic comparison of pathogenic variants of the RNA exosome gene <i>EXOSC3/RRP40</i> in <i>Saccharomyces cerevisiae</i> reveals variant-specific functional consequencesDOI 10.64898/2026.07.29.741578
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