Article
Nuclear mRNA Surveillance Mechanisms: Function and Links to Human Disease.
Journal of molecular biology - 6 Jul 2018
Singh Pragyan, Saha Upasana, Paira Sunirmal, Das Biswadip
Abstract excerpt
Production of export-competent mRNAs involves transcription and a series of dynamic processing and modification events of pre-messenger RNAs in the nucleus. Mutations in the genes encoding the transcription and mRNP processing machinery and the complexities involved in the biogenesis events lead to the formation of aberrant messages. These faulty transcripts are promptly eliminated by the nuclear RNA exosome and...
Topics
- Cell Nucleus
- Exosomes
- Humans
- Mutation
- Organ Specificity
- Prospective Studies
- RNA, Messenger
- Ribonucleoproteins
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription, Genetic