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Article

The RNA exosome and RNA exosome-linked disease.

RNA (New York, N.Y.) - 1 Feb 2018

Morton Derrick J, Kuiper Emily G, Jones Stephanie K, Leung Sara W, Corbett Anita H, Fasken Milo B

Abstract excerpt

The RNA exosome is an evolutionarily conserved, ribonuclease complex that is critical for both processing and degradation of a variety of RNAs. Cofactors that associate with the RNA exosome likely dictate substrate specificity for this complex. Recently, mutations in genes encoding both structural subunits of the RNA exosome and its cofactors have been linked to human disease. Mutations in the RNA exosome genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29093021
DOI: 10.1261/rna.064626.117
PMCID: PMC5769741

Genes

EXOSC2
EXOSC3
EXOSC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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