Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of hematopoietic loss of Y chromosome with valvular heart disease incidence and sex susceptibility

2 Jun 2025

Abstract excerpt

INTRODUCTION: Hematopoietic mosaic Loss Of Y chromosome (LOY), a condition referring to the age-related loss of Y chromosome in a subset of blood cells, is associated with shortened life expectancy and increased risk of age-related diseases in men. Despite Valvular Heart Disease (VHD) becoming more prevalent with aging, the underlying risk factors and mechanisms leading to sex-related differences in VHD remain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Eosinophilic Disorders and Syndromes
Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Genetic Associations and Epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40466759
DOI: 10.1016/j.jare.2025.06.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of hematopoietic loss of Y chromosome with valvular heart disease incidence and sex susceptibilityPMID 40466759Read ↗

Impact of Y loss in blood on male atherosclerosis and cardiovascular riskSemantic proximity Read ↗

Associations between mosaic loss of sex chromosomes and incident hospitalization for atrial fibrillation in the United KingdomSemantic proximity Read ↗

Circulating macrophages as the mechanistic link between mosaic loss of Y-chromosome and cardiac diseaseSemantic proximity Read ↗

Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and mortality in aging menSemantic proximity Read ↗

Sex chromosomes and cardiovascular disease.Semantic proximity Read ↗

Prognostic significance of somatic mutations in myeloid cells of men with chronic heart failure – interaction between loss of Y chromosome and clonal hematopoiesisSemantic proximity Read ↗

Associations Between Mosaic Loss of Sex Chromosomes and Incident Hospitalization for Atrial Fibrillation in the United Kingdom.Semantic proximity Read ↗

Loss of chromosome Y shapes the immune cell fate with aging in menSemantic proximity Read ↗

Mosaic loss of chromosome Y and coronary atherosclerosis in men: insights into sex differences in cardiovascular risk from the SCAPIS studySemantic proximity Read ↗

Clonal chromosomal mosaicism and loss of chromosome Y in men are risk factors for SARS-CoV-2 vulnerability in the elderlySemantic proximity Read ↗

Prognostic Significance of Somatic Mutations in Myeloid Cells of Men with Chronic Heart Failure – Interaction Between Loss of Y Chromosome and Clonal HaematopoiesisSemantic proximity Read ↗

Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.