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Article

Cohesin and human disease: lessons from mouse models.

Current opinion in cell biology - 1 Dec 2015

Singh Vijay Pratap, Gerton Jennifer L

Abstract excerpt

Cohesin is an evolutionarily conserved large ring-like multi-subunit protein structure that can encircle DNA. Cohesin affects many processes that occur on chromosomes such as segregation, DNA replication, double-strand break repair, condensation, chromosome organization, and gene expression. Mutations in the genes that encode cohesin and its regulators cause human developmental disorders and cancer. Several mouse...

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Identifiers

PMID: 26343989
DOI: 10.1016/j.ceb.2015.08.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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