Article

The soluble epoxide hydrolase inhibitor TPPU alleviates Aβ-mediated neuroinflammatory responses in Drosophila and cellular models of Alzheimer's disease

2023-10-30

Abstract excerpt

<title>Abstract</title> <p>Background Alzheimer's disease (AD) is a common neurodegenerative disease, and its pathogenesis is closely associated with neuroinflammation. The control of neuroinflammation in AD is the focus of current research. sEH is increased in the brain tissues of patients with AD, and sEH induces nerve inflammation by degrading epoxyeicosatrienoic acids (EETs). Therefore, sEH inhibitor applica...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5ca5e982-dbb2-53f3-8561-0b01b0a97ef7
DOI: 10.21203/rs.3.rs-3481982/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The soluble epoxide hydrolase inhibitor TPPU alleviates Aβ-mediated neuroinflammatory responses in Drosophila and cellular models of Alzheimer's diseaseDOI 10.21203/rs.3.rs-3481982/v1Read

Inhibition of Soluble Epoxide Hydrolase Confers Neuroprotection and Restores Microglial Homeostasis in a Tauopathy Mouse ModelSemantic proximity Read

Behavioural effects and RNA-seq analysis of Aβ42 mediated toxicity in a Drosophila Alzheimer’s disease modelSemantic proximity Read

A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eyeSemantic proximity Read

pGluAβ increases accumulation of Aβ in vivo and exacerbates its toxicitySemantic proximity Read

Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly.Semantic proximity Read

Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model.Semantic proximity Read

Caralluma dalzielii as a Potential Therapy for Alzheimer’s Disease: Insights from a Transgenic Drosophila melanogaster ModelSemantic proximity Read

Anti-inflammatory action of donepezil ameliorates tau pathology, synaptic loss, and neurodegeneration in a tauopathy mouse model.Semantic proximity Read

Glial Draper Rescues Aβ Toxicity in aDrosophilaModel of Alzheimer's DiseaseSemantic proximity Read

A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster.Semantic proximity Read

Alzheimer′s disease: the silver tsunami of the 21 <sup>st</sup> centurySemantic proximity Read

Ageing Increases Vulnerability to Aβ42 Toxicity in DrosophilaSemantic proximity Read