Article

Distinct prophase arrest mechanisms in human male meiosis

2017-09-28

Abstract excerpt

To prevent chromosomal aberrations to be transmitted to the offspring, strict meiotic checkpoints are in place to remove aberrant spermatocytes. However, in about 1% of all males these checkpoints cause complete meiotic arrest leading to azoospermia and subsequent infertility. We here unravel two clearly distinct meiotic arrest mechanisms that act during the prophase of human male meiosis. Type I arrested spermato...

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Literature Corpus work: d04df141-85eb-5c9e-ab6d-a423b56ad777
DOI: 10.1101/195321

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