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Article

Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.

PLoS genetics - 4 Nov 2010

Shin Yong-Hyun, Choi Youngsok, Erdin Serpil Uckac, Yatsenko Svetlana A, Kloc Malgorzata, Yang Fang, Wang P Jeremy, Meistrich Marvin L, Rajkovic Aleksandar

Abstract excerpt

Meiosis is unique to germ cells and essential for reproduction. During the first meiotic division, homologous chromosomes pair, recombine, and form chiasmata. The homologues connect via axial elements and numerous transverse filaments to form the synaptonemal complex. The synaptonemal complex is a critical component for chromosome pairing, segregation, and recombination. We previously identified a novel germ...

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Source

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Identifiers

PMID: 21079677
DOI: 10.1371/journal.pgen.1001190
PMCID: PMC2973818

Genes

ATR
BRCA1
HORMAD1
DMC1
RAD51
SYCP2
SYCP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.PMID 21079677Read ↗

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The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair.Semantic proximity Read ↗

The BRCA1-BARD1 complex associates with the synaptonemal complex and pro-crossover factors and influences RAD-51 dynamics during <i>Caenorhabditis elegans</i> meiosisSemantic proximity Read ↗

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