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Article

Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium

2018-06-07

Abstract excerpt

Mutations activating the KRAS GTPase or the BRAF kinase are frequent in colorectal cancer and are thought to constitutively activate the terminal mitogen-activated protein kinase, ERK. Using mass cytometry, we found graded phosphorylation of ERK anti-correlated with cell differentiation in patient-derived colorectal cancer organoids, independent of KRAS mutational status. Reporter, single cell transcriptome and ma...

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Literature Corpus work
58c2b79a-c3a2-50bb-af60-545c3859e2b1
DOI
10.1101/340844
Open publication

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Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epitheliumDOI 10.1101/340844
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