Article

Collateral sensitivity to β-lactam drugs in drug-resistant tuberculosis is driven by the transcriptional wiring of BlaI operon genes

2017-12-01

Abstract excerpt

<h4>Background:</h4> The evolution and spread of antimicrobial resistance is a major global public health threat. In some cases the evolution of resistance to one antimicrobial seemingly results in enhanced sensitivity to another (known as ‘collateral sensitivity’). This largely underexplored phenomenon represents a fascinating evolutionary paradigm that opens new therapeutic possibilities for patients infected w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2706fa43-25ed-5360-b387-d756336bfab0
DOI: 10.1101/227538

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Collateral sensitivity to β-lactam drugs in drug-resistant tuberculosis is driven by the transcriptional wiring of BlaI operon genesDOI 10.1101/227538Read

A chemical-genetic map of the pathways controlling drug potency in Mycobacterium tuberculosisSemantic proximity Read

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosisSemantic proximity Read

Deciphering the transcriptomic landscape of pyrazinamide resistance in Mycobacterium tuberculosisSemantic proximity Read

The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis.Semantic proximity Read

Transcriptomic signatures predict regulators of drug synergy and clinical regimen efficacy against TuberculosisSemantic proximity Read

Genome scale CRISPRi reveals both shared and strain-specific vulnerabilities in genetically diverse drug-resistant strains of Mycobacterium tuberculosis.Semantic proximity Read

Ancestral antibiotic resistance in Mycobacterium tuberculosisSemantic proximity Read

Hierarchy and networks in the transcriptional response of Mycobacterium abscessus to antibioticsSemantic proximity Read

Beyond mecA: a two-tiered mechanism and regulatory rewiring drive high-level ceftaroline resistance in clinical MRSA.Semantic proximity Read

Encoded metabolic remodeling amplifies drug resistance in Mycobacterium tuberculosisSemantic proximity Read

Collateral sensitivity of antibiotic-resistant microbes.Semantic proximity Read

Hierarchy and interconnected networks in the WhiB7 mediated transcriptional response to antibiotic stress in Mycobacterium abscessusSemantic proximity Read