Article

Encoded metabolic remodeling amplifies drug resistance in <i>Mycobacterium tuberculosis</i>

2026-05-06

Abstract excerpt

Antibiotic pressure causes pathogens to evolve many forms of altered drug susceptibility. In addition to target or activator mutations conferring canonical drug resistance, mutations can serve as steppingstones to or enhancers of resistance. In clinical strains of Mycobacterium tuberculosis (Mtb), we find that idsA2, which encodes an isoprenyl pyrophosphate synthase involved in the synthesis of precursors for es...

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Literature Corpus work: 1772fe5d-bfdd-50e4-984c-2d23c93f385b
DOI: 10.64898/2026.05.05.722911

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