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Article

Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer's disease.

Trends in neurosciences - 1 Jun 2023

Young-Pearse Tracy L, Lee Hyo, Hsieh Yi-Chen, Chou Vicky, Selkoe Dennis J

Abstract excerpt

Alzheimer's disease (AD) manifests along a spectrum of cognitive deficits and levels of neuropathology. Genetic studies support a heterogeneous disease mechanism, with around 70 associated loci to date, implicating several biological processes that mediate risk for AD. Despite this heterogeneity, most experimental systems for testing new therapeutics are not designed to capture the genetically complex drivers of...

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Identifiers

PMID: 37019812
DOI: 10.1016/j.tins.2023.03.005
PMCID: PMC10192069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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