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Protective Genes Against Alzheimer’s Disease: Case Review and Therapeutic Implications

1 Jan 2025

Abstract excerpt

Alzheimer's disease (AD), a neurodegenerative disorder characterized by the accumulation of amyloid-beta plaques and tau tangles, shows cognitive decline.Recent genetic studies have identified over 30 variants that are resilient to AD pathology, offering new therapeutic opportunities.This review explores key protective mutations of APOE3 Christchurch, RELN-COLBOS, FN1, APP A673T, BDNF Val66Met, SORL1, CR1, TREM2,...

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PMID: 40321438
DOI: 10.12779/dnd.2025.24.2.75

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