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Article

Inferring B Cell Phylogenies from Paired H and L Chain BCR Sequences with Dowser.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2024

Jensen Cole G, Sumner Jacob A, Kleinstein Steven H, Hoehn Kenneth B

Abstract excerpt

Abs are vital to human immune responses and are composed of genetically variable H and L chains. These structures are initially expressed as BCRs. BCR diversity is shaped through somatic hypermutation and selection during immune responses. This evolutionary process produces B cell clones, cells that descend from a common ancestor but differ by mutations. Phylogenetic trees inferred from BCR sequences can...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38557795
DOI: 10.4049/jimmunol.2300851
PMCID: PMC11073909

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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