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Evasion of affinity-based selection in germinal centers by Epstein–Barr virus LMP2A

24 Aug 2015

Abstract excerpt

Epstein-Barr virus (EBV) infects germinal center (GC) B cells and establishes persistent infection in memory B cells. EBV-infected B cells can cause B-cell malignancies in humans with T- or natural killer-cell deficiency. We now find that EBV-encoded latent membrane protein 2A (LMP2A) mimics B-cell antigen receptor (BCR) signaling in murine GC B cells, causing altered humoral immune responses and autoimmune...

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PMID: 26305967
DOI: 10.1073/pnas.1514484112

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