Article

Microbiota-specific serum IgG links gut and joints through immune–endothelial crosstalk in arthritis

2026-02-02

Abstract excerpt

Rheumatoid arthritis (RA) pathogenesis involves early gut immune alterations that precede clinical onset and systemic bone involvement. Using mouse and human imaging mass cytometry (IMC) and tissue sequencing, this study shows that intestinal endothelial and immune changes emerge before or coincide with arthritis symptom development. In the collagen-induced arthritis (CIA) model, intestinal vascular permeability a...

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Literature Corpus work: 7cf1e606-7117-5cc3-ac48-e1d43583722b
DOI: 10.64898/2026.01.29.702529

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