Article
Genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis.
Annals of the rheumatic diseases - 1 Jan 2017
Lau Max C, Keith Patricia, Costello Mary-Ellen, Bradbury Linda A, Hollis Kelly A, Thomas Ranjeny, Thomas Gethin P, Brown Matthew A, Kenna Tony J
Abstract excerpt
OBJECTIVES: Ankylosing spondylitis (AS) is a highly heritable immune-mediated arthropathy. Inflammation in AS is poorly understood. TBX21 encodes T-bet, a transcription factor, lying within a locus with genome-wide significant association with AS. T-bet is implicated in innate and adaptive immunity. However, the role of T-bet in AS pathogenesis is unclear. METHODS: We assessed the importance of T-bet in disease...
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