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Article

ZAP-70 genotype disrupts the relationship between microbiota and host, leading to spondyloarthritis and ileitis in SKG mice.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Oct 2014

Rehaume Linda M, Mondot Stanislas, Aguirre de Cárcer Daniel, Velasco Jared, Benham Helen, Hasnain Sumaira Z, Bowman Jaclyn, Ruutu Merja, Hansbro Philip M, McGuckin Michael A, Morrison Mark, Thomas Ranjeny

Abstract excerpt

OBJECTIVE: The spondyloarthritides share genetic susceptibility, interleukin-23 (IL-23) dependence, and the involvement of microbiota. The aim of the current study was to elucidate how host genetics influence gut microbiota and the relationship between microbiota and organ inflammation in spondyloarthritides. METHODS: BALB/c ZAP-70(W163C) -mutant (SKG) mice, Toll-like receptor 4 (TLR-4)-deficient SKG mice, and...

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PMID: 25048686
DOI: 10.1002/art.38773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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