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SARS-CoV-2 breakthrough infections induce somatically hypermutated broadly neutralizing antibodies against heterologous variants

2022-06-29

Abstract excerpt

<title>Abstract</title> <p>Currently circulating SARS-CoV-2 Omicron variants feature highly mutated spike proteins with extraordinary abilities in evading acute-infection-induced germline antibodies isolated earlier in the pandemic. We identified that memory B cells from Delta variant breakthrough-infection patients expressed antibodies with more extensive somatic hypermutations (SHMs) allowing isolation of a num...

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Literature Corpus work
916fcdb7-adbb-53c7-9b28-bba58068fac0
DOI
10.21203/rs.3.rs-1739426/v1
Open publication

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SARS-CoV-2 breakthrough infections induce somatically hypermutated broadly neutralizing antibodies against heterologous variantsDOI 10.21203/rs.3.rs-1739426/v1
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