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A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversification

8 Oct 2024

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has resulted in viral escape from clinically authorized monoclonal antibodies (mAbs), creating a need for mAbs that are resilient to epitope diversification. Broadly neutralizing coronavirus mAbs that are sufficiently potent for clinical development and retain activity despite viral evolution remain elusive. We identified a human mAb,...

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PMID: 39383863
DOI: 10.1016/j.cell.2024.09.026

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