Article

Aging restricts maturation of CXCL13 <sup>+</sup> T follicular helper cells in human immunity

2026-04-07

Abstract excerpt

A decline in specific antibody responses is a hallmark of human aging, yet the differential contributions of B and T lymphocytes and their interactions remain unclear. CXCL13 is a critical chemokine that shapes germinal center organization, but the regulation of human-specific CXCL13 + Tfh cells during aging is not known. Using human tonsil organoids, single-cell RNA sequencing, and CRISPR perturbations, we mappe...

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Literature Corpus work: 2680ba7a-58ba-58f4-afec-ba4acdb42d41
DOI: 10.64898/2026.04.03.715992

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