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Article

Drivers of the Warburg phenotype.

Cancer journal (Sudbury, Mass.) - 1 Jan 2000

Cairns Rob A

Abstract excerpt

The Warburg effect was first described by Otto Warburg in the 1920s and describes the preferential conversion of glucose to lactate as opposed to its metabolism through the citric acid cycle to fuel oxidative phosphorylation in the mitochondria, even in the presence of oxygen. This phenotype is a common feature of malignant cells and is also observed in some highly proliferative normal tissues. The selective...

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Source

Identifiers

PMID: 25815844
DOI: 10.1097/PPO.0000000000000106

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