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Article

Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity

2024-07-30

Abstract excerpt

<h4>Summary</h4> Senescence has been demonstrated to either inhibit or promote tumorigenesis. Resolving this paradox requires spatial mapping and functional characterization of senescent cells in the native tumor niche. Here, we identified senescent p16 Ink4a + cancer-associated fibroblasts with a secretory phenotype that promotes fatty acid uptake and utilization by aggressive lung adenocarcinoma driven by Kra...

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Identifiers and source

Literature Corpus work
e23cc318-9b3f-5621-bf3a-c91b6d578f8b
DOI
10.1101/2024.07.29.605645
Open publication

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Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticityDOI 10.1101/2024.07.29.605645
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